Phthalates are a family of chemicals used to make plastics more flexible and durable.[3] They also serve as solvents and stabilizers in personal care products.[1] Different phthalates perform different functions across plastic and fragrance formulations. On ingredient labels, they may appear under names such as dibutyl phthalate (DBP), di(2-ethylhexyl) phthalate (DEHP), or diethyl phthalate (DEP), and are also used in some fragrance formulations.[1]
Why It Matters
Their widespread use creates repeated opportunities for exposure through products used, handled, and consumed every day. Although the body metabolizes phthalates relatively quickly,[4] near-constant contact remains a concern. Research links phthalate exposure to endocrine disruption,[2][3] preterm birth,[5] obesity,[8][9] respiratory problems,[7][8] reproductive harm,[1][10][11][12][13] and certain cancers.[14][15][16] Pregnant people and children are of particular concern because exposure can occur during critical stages of growth and development.
Where It’s Found
Phthalates are found in polyvinyl chloride (PVC) products, plastic food packaging and containers, some medical devices and extended-release medications, air fresheners, tampons, cosmetics, and fragranced personal care products.[1] Ingredient labels may identify a specific phthalate, but products that list only “fragrance” or “parfum” may not disclose every component of the fragrance formulation.
75%+
U.S. urine samples with four common phthalate metabolites detected in a national study [17]
12 Hrs
Approximate half-life of phthalate monoesters [4]
Found In
Fragrances and parfums PVC products Plastic food packaging and containers Some medical devices and medications Tampons Air fresheners Cosmetics
Phthalates make plastics flexible and help fragrances last, but repeated exposure can interfere with the hormones that guide growth, fertility, and development.
The Health Concern
Phthalates are endocrine-disrupting chemicals, meaning they can interfere with the body’s hormonal systems by mimicking or blocking natural hormones.[2][3] Phthalate monoesters have an approximate 12-hour half-life,[4] but the chemicals’ widespread use creates ongoing opportunities for exposure.
Research has linked prenatal phthalate exposure to preterm birth.[5] Children are also a population of concern because of their smaller size and critical stages of development. Epidemiological studies have associated phthalate exposure with early-onset puberty,[7] obesity,[8][9] respiratory problems, and asthma in children.[7][8]
In adults, phthalate exposure has been linked to reproductive toxicity.[1] Research has identified several possible mechanisms, including interference with hormone release, receptors, cellular signaling, and gene expression.[10] Studies have also associated exposure with reduced male fertility, lower sperm quality, and DNA damage in sperm.[11][12][13] These findings add to concern about chronic, consistent exposure across multiple sources. Certain phthalates, including dibutyl phthalate (DBP) and di(2-ethylhexyl) phthalate (DEHP), have also been linked to increased cancer risk in humans.[15][16]
Research on phthalates spans prenatal development, childhood health, reproductive effects, and cancer. Individual studies address different chemicals and populations, but together they support concern about repeated exposure across many sources rather than a single product. Because phthalates can be present in plastics, packaging, fragrance, cosmetics, and other daily-use goods, reducing exposure requires attention to both ingredient labels and product materials.
How to Avoid It
To reduce exposure, consumers can choose products labeled “phthalate-free” and check ingredient lists for names containing the suffix “-phthalate,” including dibutyl phthalate (DBP), di(2-ethylhexyl) phthalate (DEHP), diethyl phthalate (DEP), diisodecyl phthalate (DIDP), and diisononyl phthalate (DINP).
Products that list only “fragrance” or “parfum” may contain undisclosed ingredients, including phthalates.[1] Fragrance-free products or scented products with full ingredient disclosure offer more transparency. Plastic food containers and kitchenware can be replaced with glass or stainless steel, and choosing whole foods can reduce contact with plastic packaging.
Period products that fully disclose their materials provide another way to avoid phthalate-containing plastics.
Choosing fewer fragranced products where scent is not essential can further reduce potential exposure.
[1] Patel, S. (2017). Fragrance compounds: The wolves in sheep’s clothings. Medical Hypotheses, 102, 106–111. https://doi.org/10.1016/j.mehy.2017.03.025
[2] Shanna H Swan: Environmental exposure to chemicals and their consequences for human fertility. (2025). Bulletin of the World Health Organization, 103(4), 236–237. https://doi.org/10.2471/BLT.25.030425
[3] Arrigo, F., Impellitteri, F., Piccione, G., & Faggio, C. (2023). Phthalates and their effects on human health: Focus on erythrocytes and the reproductive system. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 270, 109645. https://doi.org/10.1016/j.cbpc.2023.109645
[4] Hoppin, J. A., Brock, J. W., Davis, B. J., & Baird, D. D. (2002). Reproducibility of urinary phthalate metabolites in first morning urine samples. Environmental Health Perspectives, 110(5), 515–518. https://doi.org/10.1289/ehp.02110515
[5] Trasande, L., Nelson, M. E., Alshawabkeh, A., Barrett, E. S., Buckley, J. P., Dabelea, D., Dunlop, A. L., Herbstman, J. B., Meeker, J. D., Naidu, M., Newschaffer, C., Padula, A. M., Romano, M. E., Ruden, D. M., Sathyanarayana, S., Schantz, S. L., Starling, A. P., Hamra, G. B., & programme collaborators for Environmental influences on Child Health Outcomes. (2024). Prenatal phthalate exposure and adverse birth outcomes in the USA: A prospective analysis of births and estimates of attributable burden and costs. The Lancet. Planetary Health, 8(2), e74–e85. https://doi.org/10.1016/S2542-5196(23)00270-X
[6] Doherty, B. T., McRitchie, S. L., Pathmasiri, W. W., Stewart, D. A., Kirchner, D., Anderson, K. A., Gui, J., Madan, J. C., Hoen, A. G., Sumner, S. J., Karagas, M. R., & Romano, M. E. (2022). Chemical exposures assessed via silicone wristbands and endogenous plasma metabolomics during pregnancy. Journal of Exposure Science & Environmental Epidemiology, 32(2), 259–267. https://doi.org/10.1038/s41370-021-00394-6
[7] Jurewicz, J., & Hanke, W. (2011). Exposure to phthalates: Reproductive outcome and children health. A review of epidemiological studies. International Journal of Occupational Medicine and Environmental Health, 24(2), 115–141. https://doi.org/10.2478/s13382-011-0022-2
[8] Day, D. B., LeWinn, K. Z., Karr, C. J., Loftus, C. T., Carroll, K. N., Bush, N. R., Zhao, Q., Barrett, E. S., Swan, S. H., Nguyen, R. H. N., Trasande, L., Moore, P. E., Adams Ako, A., Ji, N., Liu, C., Szpiro, A. A., & Sathyanarayana, S. (2024). Subpopulations of children with multiple chronic health outcomes in relation to chemical exposures in the ECHO-PATHWAYS consortium. Environment International, 185, 108486. https://doi.org/10.1016/j.envint.2024.108486
[9] Kim, S. H., & Park, M. J. (2014). Phthalate exposure and childhood obesity. Annals of Pediatric Endocrinology & Metabolism, 19(2), 69–75. https://doi.org/10.6065/apem.2014.19.2.69
[10] Hlisníková, H., Petrovičová, I., Kolena, B., Šidlovská, M., & Sirotkin, A. (2020). Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review. International Journal of Environmental Research and Public Health, 17(18), 6811. https://doi.org/10.3390/ijerph17186811
[11] Kamrin, M. A. (2009). Phthalate risks, phthalate regulation, and public health: A review. Journal of Toxicology and Environmental Health. Part B, Critical Reviews, 12(2), 157–174. https://doi.org/10.1080/10937400902729226
[12] Duty, S. M., Silva, M. J., Barr, D. B., Brock, J. W., Ryan, L., Chen, Z., Herrick, R. F., Christiani, D. C., & Hauser, R. (2003). Phthalate exposure and human semen parameters. Epidemiology (Cambridge, Mass.), 14(3), 269–277.
[13] Hauser, R., Meeker, J. D., Singh, N. P., Silva, M. J., Ryan, L., Duty, S., & Calafat, A. M. (2007). DNA damage in human sperm is related to urinary levels of phthalate monoester and oxidative metabolites. Human Reproduction, 22(3), 688–695. https://doi.org/10.1093/humrep/del428
[14] Hsieh, T.-H., Tsai, C.-F., Hsu, C.-Y., Kuo, P.-L., Lee, J.-N., Chai, C.-Y., Wang, S.-C., & Tsai, E.-M. (2012). Phthalates induce proliferation and invasiveness of estrogen receptor-negative breast cancer through the AhR/HDAC6/c-Myc signaling pathway. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 26(2), 778–787. https://doi.org/10.1096/fj.11-191742
[15] Wu, A. H., Franke, A. A., Wilkens, L. R., Tseng, C., Conroy, S. M., Li, Y., Polfus, L. M., De Rouen, M., Caberto, C., Haiman, C., Stram, D. O., Le Marchand, L., & Cheng, I. (2021). Urinary phthalate exposures and risk of breast cancer: The Multiethnic Cohort study. Breast Cancer Research, 23(1), 44. https://doi.org/10.1186/s13058-021-01419-6
[16] López-Carrillo, L., Hernández-Ramírez, R. U., Calafat, A. M., Torres-Sánchez, L., Galván-Portillo, M., Needham, L. L., Ruiz-Ramos, R., & Cebrián, M. E. (2010). Exposure to phthalates and breast cancer risk in northern Mexico. Environmental Health Perspectives, 118(4), 539–544. https://doi.org/10.1289/ehp.0901091
[17] Silva, M. J., Barr, D. B., Reidy, J. A., Malek, N. A., Hodge, C. C., Caudill, S. P., Brock, J. W., Needham, L. L., & Calafat, A. M. (2004). Urinary levels of seven phthalate metabolites in the U.S. population from NHANES 1999-2000. Environmental Health Perspectives, 112(3), 331-338. https://stacks.cdc.gov/view/cdc/3849